Carbene?Catalyzed Enantioselective Hydrophosphination of ??Bromoenals to Prepare Phosphine?Containing Chiral Molecules

Disclosed herein is the first carbene-organocatalyzed asymmetric addition of phosphine nucleophiles to in situ generated ?,?-unsaturated acyl azolium intermediates. Our reaction enantioselectively constructs carbon–phosphine bonds and prepares chiral phosphines with high optical purities. The products are suitable for transforming ligands or catalysts applications catalysis. diarylalkyl trialkyl from our catalytic reactions, air-sensitive reactive nature, can be trapped (and stored) their sulfur-oxidized form operational simplicities.